The Buffalo Bills host the Jacksonville Jaguars on Monday night with a chance at opening a season with three straight wins for the first time since 2020, and third time since coach Sean McDermott's arrival in 2017.

The Jacksonville Jaguars will play on Monday Night Football this week for the 2nd time since 2011. Here's what to know before they take on the Bills

It has only been two weeks to start the regular season, but the Buffalo Bills have already gone through a plethora of injuries to their top defensive players.  That seems to be continuing for another week.